Citrus and grape compounds and diabetes
Health Notes 040626
Here is one of our latest natural health and nutrition findings:
Research shows citrus and grape compounds may protect against type 2 diabetes
University of Napoli (Italy), Nov 2 2025 (News-Medical)
In a recent study published in the journal Frontiers in Nutrition, researchers investigated whether a novel food supplement could improve metabolic health in people with impaired fasting glucose (IFG). The study comprised a single-center, six-month, randomized, double-blind, placebo-controlled trial wherein 62 subjects with IFG were placed on a healthy diet. Half of the included participants received a supplement containing citrus and red grape extracts, hesperidin, and chromium (250 µg chromium and 560 mg total flavonoids per day).
The study enrolled 62 Italian adults (ages 18–75) diagnosed with IFG (fasting blood glucose levels of 100–125 mg/dL). Participants were randomly assigned to either the supplement or placebo group. The treatment group received two tablets daily (after lunch and dinner) for six months, while both groups followed an isocaloric DASH (Dietary Approaches to Stop Hypertension) diet. Use of additional glucose- or lipid-affecting supplements or drugs was prohibited. The supplement provided 250 µg of chromium and 560 mg of flavonoids derived from Citrus limon (lemon), Vitis vinifera (red grape), and Citrus sinensis(orange).
The supplement group achieved a significant reduction in fasting glucose (114 to 94 mg/dL) compared with the placebo group (113 to 107 mg/dL). HbA1c decreased significantly only in the supplement group, while insulin and HOMA-IR showed no treatment effect. Lipid outcomes were also favorable, with LDL-C decreasing from 114 to 73 mg/dL, HDL-C increasing from 38 to 56 mg/dL, and triglycerides declining significantly. Conversely, triglyceride levels increased in the placebo group. Aspartate transaminase (AST), alanine transaminase (ALT), and creatinine levels indicated excellent tolerability.
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